Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor beta 1 in hypercholesterolemic rats.
- Author:
Xiao-yun SI
1
;
Ru-han JIA
;
Cong-xin HUANG
;
Guo-hua DING
;
Hong-yan LIU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Hypercholesterolemia; metabolism; pathology; Kidney Glomerulus; metabolism; Male; Phytotherapy; Plant Roots; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Transforming Growth Factor beta; metabolism; Transforming Growth Factor beta1; Valerian; chemistry
- From: China Journal of Chinese Materia Medica 2003;28(9):845-848
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of Valeriana officinalis var latifolia(VOL) on expression of transforming growth factor beta 1 (TGF-beta 1) in hypercholesterolemic rats and study its possible mechanisms.
METHODDietary-induced hypercholesterolemia was induced in male Wistar rats by given 4% cholesterol and 1% cholic acid diet for 16 weeks. Changes of serum lipid, urinary albumin, renal function and Mesangial matrix index were assessed. Moreover, immunohistochemical stain for TGF-beta 1 and type IV collagen were performed.
RESULTVOL could reduce the serum levels of total cholesterol, low density lipoprotein, urinary albumin and serum creatinine. Light microscopy and immunohistochemical stain revealed that in the same time of lowing serum lipid, Mesangial matrix index was significantly reduced, accompanied by decreased expression of TGF-beta 1 and type IV collagen.
CONCLUSIONVOL has the protective effect on lipid-induced nephropathy, and the inhibition of TGF-beta 1 expression might be the mechanism of VOL on renal protection.
