Antioxidation activity and protective effection of ginger oil on DNA damage in vitro.
- Author:
Ping LU
1
;
Bing-sen LAI
;
Ping LIANG
;
Zhen-tong CHEN
;
Shu-qing SHUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; pharmacology; DNA Damage; drug effects; Erythrocytes; drug effects; Ginger; chemistry; Hemolysis; drug effects; Humans; Liver; metabolism; Lymphocytes; drug effects; Malondialdehyde; metabolism; Plant Oils; isolation & purification; pharmacology; Plants, Medicinal; chemistry; Protective Agents; pharmacology; Rabbits; Reactive Oxygen Species; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(9):873-875
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the antioxidation activity and protective effect of ginger oil on DNA damage.
METHODChemical light assay was used to detect the oxygen radicals scavenging capacity of ginger oil. The erythrocyte oxidation damage was induced by H2O2. The effect of ginger oil on oxidative erythrocyte was observed by the colorimetric analysis assay, and the content of malondialdehyde (MDA) in rabit hepatocyte was measured. The anaylsis of DNA damage was made with single cell gel electrophoresis(SCGE) technique.
RESULTGinger oil might decrease light value compared with control group and inhibited erythrocyte oxidation damage. Compared with that in control group, the degress of DNA damage reduced significantly in the protected groups. Ginger oil might decrease the content of MDA remarkably and inhitibition rate was 48.16%.
CONCLUSIONGinger oil has dominantive protective effect on DNA damage induced by H2O2. Ginger oil might act as a scavenger of oxygen radical and might be used as an antioxidant.
