Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae.
- Author:
Ming-xing PENG
1
;
Yong-jiang WU
;
Yi-yu CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Berberine; analogs & derivatives; analysis; Berberine Alkaloids; analysis; Chromatography, High Pressure Liquid; Coptis; chemistry; Drug Combinations; Drugs, Chinese Herbal; analysis; Evodia; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Solubility
- From: China Journal of Chinese Materia Medica 2003;28(7):629-632
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the solubility of Rhizoma Coptidis' main chemical constituents and the proportion of Rhizoma Coptidis and Fructus Evodiae.
METHOD9 samples were selected in which the proportion of Rhizoma Coptidis and Fructus Evodiae were 1:0, 6:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:6 and 0:1, respectively. The samples' water-extracts were analyzed by RP-HPLC. Then solubility changes of eight chemical constituents were calculated, and the regression equations were established.
RESULTAmong the eight chemical constituents, one was independent on the change of proportion of Rhizoma Coptidis and Fructus Evodiae, six having linear relationship. A new constituent was detected, and there was nonlinear relationship between its quantity and the proportion of the couple.
CONCLUSIONThe solubility of Rhizoma Coptidis' main chemical constituents declines almost in the same scale when Rhizoma Coptidis and Fructus Evodiae are used as a couple, and a new constituent has been detected which can't be found in the mono-extraction.
