Effect of Cryptoporus volvatus (Peck) Schear on leukotriene production from polymorphonuclear leukocytes in rats.
- Author:
Sai-hong JIN
1
;
Qiang-min XIE
;
Xiao-xia LIN
;
Yang-mei DENG
;
Ji-qiang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Asthmatic Agents; pharmacology; Anti-Inflammatory Agents, Non-Steroidal; pharmacology; Cell Separation; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Guinea Pigs; Leukotriene B4; metabolism; Male; Neutrophils; metabolism; Polyporaceae; chemistry; Rats; Rats, Sprague-Dawley; SRS-A; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(7):650-653
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study action of Cryptoporus volvatus ferment substance (CVFS) on leukotriene production of polymorphonuclear leukocytes in rats.
METHODSThe level of slow reaction substance (SRS) and leukotriene B4 (LTB4) in polymorphonuclear leukocytes (PMNs) in rats in vitro were determined with bioassay and HPLC.
RESULTSCVFS 0.9, 2.7 g.kg-1 by ig significantly inhibited SRS and LTB4 production in PMNs in rats in vivo.
CONCLUSIONThe inhibition effect of CVFS on SRS and LTB4 release may be related to its mechanism of anti-inflammation and anti-asthma.
