Adjustive effect of yi qi tong lin chongji on the three growth factors in rats prostatic tissues.
- Author:
Zheng-guo MI
1
;
Su-xiang LIU
;
Yong-qing CAO
;
Xiao-feng YANG
Author Information
- Publication Type:Journal Article
- MeSH: Aconitum; chemistry; Animals; Cinnamomum aromaticum; chemistry; Diethylstilbestrol; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Fibroblast Growth Factor 2; metabolism; Male; Plants, Medicinal; chemistry; Prostate; metabolism; pathology; Prostatic Hyperplasia; chemically induced; metabolism; pathology; Rats; Rats, Wistar; Rehmannia; chemistry; Testosterone Propionate; Transforming Growth Factor beta; metabolism; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(7):653-655
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mechanisim of Yi Qi Tong Lin Chingji in treating benign prostatic hyperplasia.
METHODThe expressions of VEGF, bFGF and TGF beta 1 in prostatic hyperplasia model rats were examined by immunohistochemistry. 8 rats were in contrastive group, 24 influenced by Yi Qi Tong Ling Chingji and Prostacar.
RESULTThe expressions of VEGF and bFGF were significantly difference, but the expression of TGF beta 1 was not significant. (P < 0.01). The expression of VEGF and bFGF were significant in contrastive group to the high-dose of Yi Qi Tong Ling Chingji and Prostacar group (P < 0.05) but were not significant to the low-dose of Yi Qi Tong Ling Chingji group. There was no significant difference between high-dose of Yi Qi Tong Ling Chingji and Prostacar group and three growth factors.
CONCLUSIONYi Qi Tong Ling Chingji inhibit the expression of VEGF and bFGF in BPH so as to decrease the volume of prostate.
