Studies on liver-toxicity in rhigoma of Dioscorea bulbifera.
- Author:
Xing-qi TAN
1
;
Jin-lan RUAN
;
Hai-sheng CHEN
;
Ju-ying WANG
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Bilirubin; blood; Chemical and Drug Induced Liver Injury; blood; etiology; pathology; Dioscorea; chemistry; Drugs, Chinese Herbal; toxicity; Female; Liver; pathology; ultrastructure; Male; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2003;28(7):661-663
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera.
METHODThe rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope.
RESULTT001 and F002 showed significant liver toxicity.
CONCLUSIONThe chloroform fraction was the liver-toxic fraction of D. bulbifera.
