Yixintong tablet's protection against experimental myocardial ischemia.
- Author:
Jin-hua PIAO
1
;
Pei-zhi TONG
;
Hong ZHANG
;
Tian-hong GAO
;
Li ZHANG
;
Xiang-hua LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Pressure; drug effects; Cardiotonic Agents; administration & dosage; pharmacology; Crataegus; chemistry; Drugs, Chinese Herbal; administration & dosage; pharmacology; Electrocardiography; drug effects; Flavonoids; administration & dosage; isolation & purification; pharmacology; Heart Rate; drug effects; Male; Myocardial Ischemia; pathology; physiopathology; Myocardial Reperfusion Injury; pathology; physiopathology; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Tablets
- From: China Journal of Chinese Materia Medica 2003;28(5):442-445
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEVarious models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.
METHODModels of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.
RESULTA dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (+/- dp/dtmax), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary-ligatured rats. The tablet benefited the rats with pituitrin(iv)- or isoprenaline(ip)-induced acute myocardial ischemia to reverse any ST deviation and T-wave fall.
CONCLUSIONYixintong has a protective and therapeutic action to the experimental myocardial ischemia.
