Effect of different drug dosage to activate blood circulation and to nourish qi on cardiac function and structure of congestive heart failure rats after acute myocardial infarction.
- Author:
Jin-xing CHEN
1
;
Shuo-ren WANG
;
Ming-jing ZHAO
;
Xi-ying LU
;
Zhuang ZHANG
;
Ying QIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Astragalus membranaceus; chemistry; Codonopsis; chemistry; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacology; Heart; physiopathology; Heart Failure; etiology; pathology; physiopathology; Male; Myocardial Infarction; complications; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2003;28(5):446-449
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of different drug dosage to activate blood circulation and to nourish Qi on cardiac function and structure of heart failure rats after acute myocardial infarction.
METHODThe congestive heart failure post cardiac infarction rats models subjected to left coronary occlusion were made and given different dosage of drug of Huoxue Yiqi and captopril (positive control) from 4 weeks to 8 weeks after operation. The cardiac function before and after using drugs were observed by impedance methods.
RESULTTreated by different dosage of drug of Huoxue Yiqi and captopil, cardiac function of heart failure rats after acute myocardial infarction improved, SV, CO, CI(P < 0.01); at the same time, prescription of Huoxue Yiqi and Qixue could improve the model rats' heart coefficient, VS SHAM(P > 0.05), but prescription of Yiqi Huoxue and captopril could not improve it.
CONCLUSIONDrug to activate blood circulation and to increase qi can treat heart failure rats after acute myocardial infarction, through improving their function and structure. At the same time, more dosage of drug to activate blood circulation and to increase qi(Huoxue/Yiqi drug) may improve the model rats' heart coefficient.
