Protective effect of qi dong yi xin on acute myocardial infarction in dogs.
- Author:
Qiu-jing WANG
1
;
Weng-wei LU
;
Hang LU
;
Fen LIU
;
Shi-jie YANG
;
Yu-qiang HUA
;
Shu-xia JI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Astragalus membranaceus; chemistry; Cardiotonic Agents; administration & dosage; pharmacology; Coronary Circulation; drug effects; Dogs; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; pharmacology; Female; Male; Myocardial Infarction; pathology; physiopathology; Ophiopogon; chemistry; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2003;28(5):449-452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the protective effects on acute myocardial infarction of QDYX in dog.
METHODThe corconary ciculation and cardial oxygen metabolism, the degree and range of myocardial ischemia, myocardial infarct size, and the changes of the enzymes in serum were determined by using the acute myocardial infarction model of ligation of LAD in the anaesthetized open-chest dogs.
RESULTThe coronary resistance and cardial oxygen consumption were decreased and the myocardial blood flow was increased in dogs treated with QDYX of 1.0,2.0 mg.kg-1. The degree and range of myocardial ischemia, myocardial infarct size and the activity of serum CK, LDH were decreased in acute myocardial infarcion dogs treated with QDYX of 1.0,2.0 mg.kg-1.
CONCLUSIONQDYX can decrease cardial oxygen consumption in dogs, thus having protective effect on myocardial ischemia.
