Familial Wolff-Parkinson-White syndrome is linked to the loci on chromosome 7q3.
- Author:
Wenling LIU
1
;
Guoshu LIU
;
Dayi HU
;
Yu QI
;
Zhaoliang SHAN
;
Dayan YANG
;
Deqiang LIU
;
Yumei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Chromosome Mapping; Chromosomes, Human, Pair 7; Female; Genetic Markers; Humans; Male; Middle Aged; Tandem Repeat Sequences; Wolff-Parkinson-White Syndrome; genetics
- From: Chinese Medical Journal 2002;115(11):1733-1735
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEWolff-Parkinson-White syndrome (WPW) is considered to be an autosomal dominant hereditary disease, but the gene is not identified. The objective of this study was to localize the genetic loci of Wolff-Parkinson-White syndrome.
METHODSLinkage analysis between the disease of Wolff-Parkinson-White syndrome and 3 STR (short tandem repeats) markers on 7q3 (D7S505, D7S688, and D7S483) was tested in 3 kindreds of the Wolff-Parkinson-White syndrome (101 numbers in total) by genotyping.
RESULTSWolff-Parkinson-White syndrome was linked to the loci above. The maximum two-point Lod score detected at D7S505 was 6.4 at a recombination fraction (theta) of 0.1; the Lod score of D7S688, D7S483 was 5.3 vs 2.5.
CONCLUSIONThe gene of Wolff-Parkinson-White syndrome is located at 7q3.
