Expression of IL-17A during Thymus Regeneration in the Rat.
10.11637/kjpa.2011.24.3.141
- Author:
Hak Jong CHOI
1
;
Hee Woo LEE
;
Jong Hun PARK
;
Sae Ock OH
;
Sun Yong BAEK
;
Bong Seon KIM
;
Sik YOON
Author Information
1. Department of Anatomy, Pusan National University School of Medicine, Korea. sikyoon@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
IL-17;
IL-17A;
Thymus;
Thymic stromal cells;
Thymocytes;
Thymic epithelial cells;
Thymus regeneration
- MeSH:
Animals;
Cyclophosphamide;
Epithelial Cells;
Humans;
Interleukin-17;
Rats;
Regeneration;
RNA, Messenger;
T-Lymphocytes;
Thymocytes;
Thymus Gland
- From:Korean Journal of Physical Anthropology
2011;24(3):141-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
IL-17A is a pro-inflammatroy cytokine secreted by activated T cells. The IL-17 family consist of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17A and IL-17F are produced primarily in activated T cells. In contrast, IL-17B, IL-17C, IL-17D and IL-17E are expressed in a wide assortment of tissues. Their functions partially overlap those of IL-17A, although they have not been as thoroughly investigated. The receptor for IL-17A (IL-17R) is widely expressed in a variety of tissues. IL-17A and IL-17E mRNAs were expressed in only EL4 cells. IL-17C mRNA expression was observed in the thymic subcapsular/cortex epithelial cells (SNEC), cortex or cortical reticular cells (CREC), medullary epithelial cells (MEC), medullary interdigitating-like cells (MDC), thymocytes and EL4 cells. However, IL-17C mRNA was not expressed in RAW 264.7 cells. Immunohistochemical study also demonstrated not only the presence of IL-17A mainly in the thymic epithelial cells, but also the upregulated expression of IL-17A in the thymic epithelial cells of the regenerating thymus. Thus, the results of the present study suggest that IL-17A expressed in the thymocytes and thymic epithelial cells could play an important role in the development of new T cells to replace T cells damaged by cyclophosphamide treatment during thymus regeneration.
