Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma.
- Author:
Zhigang CAO
1
;
Zhihong WANG
1
;
Junzhong SUN
1
;
Chaojin PENG
1
;
Shaomei FENG
1
;
Xiaoyan ZHOU
1
;
Qingming YANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents, Alkylating; therapeutic use; Hodgkin Disease; drug therapy; Humans; Immunoconjugates; therapeutic use; Mechlorethamine; therapeutic use
- From: Chinese Journal of Hematology 2015;36(7):575-577
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the clinical efficacy and side effects of brentuximab vedotin (BV) plus chlormethine hydrochloride (CH) in patients with relapsed and refractory Hodgkin lymphoma (HL) after failure with BV alone.
METHODSFrom March, 2014 to December, 2014, 6 patients who failed with BV monotherapy were enrolled in this study. The chemotherapy regimen consisted of BV (1.2-1.8 mg/kg, iv. gtt, d1) and CH (6 mg/m2, iv. gtt, d1) was given for 3 weeks as one course, and all patients received about 3-8 courses of chemotherapy, with an median of 4 courses. Clinical efficacy and adverse events were assessed and observed by radiographic examination and serological detection.
RESULTSAmong 6 patients, the overall response rate was 100% with 2 complete remission and 4 partial remission. The main adverse events were grade I (2 patients) and IV (2 patients) bone marrow depression, grade II (2 patients)gastrointestinal reaction, grade I (1 patient) increase of transaminase and myocardial enzyme and grade I (1 patient) mouth ulcers.
CONCLUSIONThe combination of BV and CH in the treatment of relapsed and refractory HL after failure with BV alone was high effective and the toxicities were well tolerable.
