Study on the outline of the continuous intravenous of the small dose of insulin in the treatment of the hyperosmolar coma due to diabetes mellitus
- Author:
Huong Mai Ha
- Publication Type:Journal Article
- Keywords:
hyperosmolar coma
- MeSH:
Hyperglycemic Hyperosmolar Nonketotic Coma;
Insulin;
Diabetes Mellitus
- From:Journal of Practical Medicine
2002;435(11):30-34
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In oder to evaluate the effect of hyperglycemic control and potential complications of the recommended protocol using small doses of inssulin in treating the non- ketotic hyperosmolar diabetics. 22 studies partients were used Regular insulin with an initial dose of 0.1 IU/kg/h by continuous intravenous infusion. The dose of insulin was reduced to 0.05 IU/kg/h when the patient’s glycemia dropped to a level of 16 mmol/l. Results: 17 non ketotic hyperosmolar coma patients (77%) were successfully treated and discharged. No severe complications concerned with the inssulin therapy (such as hypoglycemia; hypokalemia) were noticed in this study. 5 patients died. The mean total dose of insulin in these patients during the first 24 h was not significantly different from that of the other survivals. Conclusions: the proposed small doses of insulin by continuous intravenous infusion showed a high and safe effect in treatment of non- ketotic hyperosmolar diabetics.
