HIV-1 Rev and related inhibitors.
- Author:
Yuan CAO
1
;
Xin-yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Active Transport, Cell Nucleus;
Amino Acid Sequence;
Anti-HIV Agents;
chemistry;
pharmacology;
Cell Nucleus;
metabolism;
Fatty Acids, Unsaturated;
chemistry;
pharmacology;
Framycetin;
chemistry;
pharmacology;
HIV-1;
genetics;
metabolism;
physiology;
Karyopherins;
metabolism;
RNA, Messenger;
genetics;
RNA, Viral;
genetics;
Receptors, Cytoplasmic and Nuclear;
metabolism;
Transcription, Genetic;
Virus Replication;
rev Gene Products, Human Immunodeficiency Virus;
antagonists & inhibitors;
metabolism
- From:
Acta Pharmaceutica Sinica
2007;42(4):347-351
- CountryChina
- Language:Chinese
-
Abstract:
HIV-1 Rev is an indispensable regulatory factor of the virion protein expression. The interaction between Rev and RRE RNA accelerates the nuclear export of viral mRNA. The unspliced and singly spliced mRNA will be degraded in the absence of Rev, resulting in the interception of HIV-1 replication at the same time. The pivotal role that Rev plays in HIV-1 replication as a trans-acting factor makes it a new target in the research of AIDS drugs. In this review, the function of Rev, Rev-RRE interaction, as well as their related inhibitors are reported.
