Recent advances in the biosynthesis of Taxol.
- Author:
Jian-qiang KONG
1
;
Wei WANG
;
Ping ZHU
;
Ke-di CHENG
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
biosynthesis;
chemical synthesis;
chemistry;
isolation & purification;
Arteriosclerosis;
prevention & control;
Genes, Plant;
Genetic Engineering;
Neoplasms;
drug therapy;
Paclitaxel;
biosynthesis;
chemical synthesis;
chemistry;
isolation & purification;
Taxoids;
chemical synthesis;
chemistry;
Taxus;
chemistry;
genetics
- From:
Acta Pharmaceutica Sinica
2007;42(4):358-365
- CountryChina
- Language:Chinese
-
Abstract:
Taxol is one of the most potent chemotherapeutic agents known, showing excellent activity against a range of cancers. In addition to anticancer, taxol has the effect of preventing graft arteriosclerosis, antiscaring formation and inhibiting angiogenesis. There are five possible routes to industrialize taxol production: isolation from the bark of the yew species, total synthesis, semisynthesis, tissue or cell culture, endophytic fungal fermentation and metabolism engineering. There are at least 14 genes related to the taxol biosynthesis had been cloned from yews and functionally expressed in different hosts. The combinational expression system of taxol makes progress as the clarification of biosynthetic pathway of taxol.
