Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics.

Author: Kyungmee CHOI ¹ ; Dong Seok YIM
Author Information

1. Division of Mathematics, College of Science and Technology, Hongik University at Sejong, Jochiwon, Sejong 339-701, South Korea.
Publication Type:Review
MeSH: Calculi; Data Interpretation, Statistical; Sample Size
From:Translational and Clinical Pharmacology 2015;23(1):8-14
CountryRepublic of Korea
Language:English
Abstract: The maximum likelihood estimator is the point estimator of the top priority in statistical data analysis because of its optimum properties for large sample size. While the maximum likelihood estimator is widely used, it has been an abstruse subject for pharmacometricians without statitics bagkround because of high dimensional calculus and asymptotic theories. This tutorial provides a general and brief introduction to the maximum likelihood estimator and its related caluculus for non-statisticians.