In vitro inhibition of respiratory syncytial virus with combined ribavirin and an oral preparation of traditional Chinese medicine Hu Fei.
- Author:
Yu-hua LIU
1
;
An-cun HOU
;
Gao-chao ZHAO
;
Feng-lian WANG
;
Shan-na WU
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; pharmacology; Drug Synergism; Drugs, Chinese Herbal; pharmacology; Humans; Microbial Sensitivity Tests; Respiratory Syncytial Virus, Human; drug effects; Ribavirin; pharmacology
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(2):187-188
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the in vitro antiviral effect of ribavirin combined with an oral preparation of traditional Chinese medicine "Hu Fei" (protecting the lung) on respiratory syncytial virus (RSV).
METHODSCytopathic effects (CEP) of RSV on Hep2 cells were observed after adding different concentrations of ribavirin, Hu Fei and combination of both into the culture medium.
RESULTSThe minimum concentration of ribavirin and Hu Fei for complete inhibition of CPE caused by RSV was 7.80 microg/ml and 5.00 mg/ml, respectively. When the combination of ribavirin and Hu Fei was applied, their minimum concentrations needed for complete inhibition were decreased to 0.98 ?g/ml and 0.63 mg/ml.
CONCLUSIONSBoth ribavirin and Hu Fei showed in vitro anti-RSV effect, but the inhibitory effect of combined ribavirin and Hu Fei was more potent than either of the preparation alone.
