Human hepatitis B virus infection of tree shrews and Macaca assamensis in vivo.
- Author:
Shu-sheng WANG
1
;
Jian-jia SU
;
Hua-yuan ZHANG
;
Yuan LI
;
Tao ZHANG
;
You-chun WANG
;
Guo-yong HUANG
;
Liu-liang QIN
;
Xian-min GE
;
Yang YU
;
He-min LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Hepatitis B; blood; immunology; virology; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Hepatitis B virus; isolation & purification; Humans; Macaca; Male; Tupaiidae
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(1):21-24
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine sensitivity of the tree shrews and Macaca assamensis to human hepatitis B virus (HHBV) by serologic methods.
METHODSTotally 233 tree shrews and 28 Macaca assamensis were inoculated with human sera containing HBV. After inoculation, the sera were collected weekly from them and HBV markers were detected with HBV ditecting ELISA kits.
RESULTSNinety percent of the tree shrews developed acute infection, among them, 44.4 % persisted for over one year, 33.3% of them developed chronic infection persisted for 2 years and one month; the persistence of HBV in Macaca assamensis was much shorter.
CONCLUSIONThese data clearly indicated that tree shrew may be used as an animal model for study of chronic HBV infection, whereas, Macaca assamensis, showed only a transient sensitivity to HHBV.
