Clinical outcomes of women with transfusion-associated hepatitis C after 10-15 years follow-up.
- Author:
Fang GUO
1
;
Yan GAO
;
Qi-xin WANG
;
De-gui SUN
;
Ying JI
;
Xu CONG
;
Yan SUN
;
Hao WANG
;
Lai WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; epidemiology; Follow-Up Studies; Hepacivirus; genetics; Hepatitis C, Chronic; epidemiology; transmission; Humans; Male; Middle Aged; RNA, Viral; blood; Transfusion Reaction
- From: Chinese Journal of Experimental and Clinical Virology 2004;18(2):132-136
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo investigate natural history of hepatitis C virus (HCV) infection and related factors in China.
METHODSTotally 41 women infected with HCV 10-15 years ago were evaluated in this study. Their clinical manifestations were recorded and sera tested for alamine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), alkaline phosphatase (ALP), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin (ALB), and alpha-fetoprotein (alpha-FP), as well as virus markers. The B-type ultrasound examination was performed on the liver, gall bladder, spleen and pancreas. For virus markers, HCV RNA was detected with fluorogenic-quantitative polymerase-chain-reaction, HBsAg and anti-HCV antibody, with enzyme-linked immunosorbent assay (ELISA).
RESULTSTen to 15 years after infection, the infection was cleared spontaneously in 8 cases (19.51%); 73%(30/41) cases had signs at present, 32% (13/41) cases had mild ALT and/or AST elevation. On ultrasound examination, 83%(34/41) had mild degree 17%(7/41) moderate degree changes of the viral hepatitis.
CONCLUSIONWomen with HCV infection for 13 +/- 1 (10-15) years after transfusion had slight hepatic inflammation. A part of them had cleared the virus spontaneously.