Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis.
- Author:
Yong-jie LI
1
;
De-xin WANG
;
Feng-min ZHANG
;
Zhan-dong LIU
;
Ai-ying YANG
;
K YKUTA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antibodies, Viral; blood; Blotting, Western; Borna Disease; complications; immunology; Borna disease virus; immunology; Fatigue Syndrome, Chronic; virology; Female; Humans; Male; Middle Aged
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(4):330-333
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the prevalence of infection with Borna disease virus (BDV) in Chinese patients with chronic fatigue syndrome (CFS) and control subjects, and to discuss the etiological association between CFS and infection with BDV.
METHODSThe CDC (1994) diagnostic criteria for CFS were used for case definition. Sixty-one patients suffered from CFS were from 11 Provinces in China. To detect the antibody against BDV-p24 on the plasma samples from all cases and 73 healthy control subjects by Western-blotting analysis.
RESULTS7 of the sixty-one cases and 0 of the controls were sero-positive for BDV-p24 antibody, there was a statistical significant difference between the two groups (11.48% vs 0%; P less than 0.010).
CONCLUSIONChinese patients with CFS showed sero-positive identifying BDV infection, by comparison, anti.BDV-p24 antibody prevalence in patients was significantly higher than in controls. An etiological association may exist between CFS and BDV infection.
