Preliminary studies on pathogenic factors of human cytomegalovirus infection.
- Author:
Ai-bin LI
1
;
Qian LIU
;
Liang-bin XIA
;
Yu-hong LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antibodies, Viral; blood; Chorionic Villi; pathology; virology; Cytomegalovirus; genetics; immunology; isolation & purification; Cytomegalovirus Infections; pathology; DNA, Viral; analysis; Decidua; pathology; virology; Female; Humans; Immunoglobulin G; blood; Immunoglobulin M; blood; Pregnancy; Pregnancy Complications, Infectious; pathology; virology
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(4):369-371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the pathogenic factors of human cytomegalovirus (HCMV) infections.
METHODSTotally 36 serum samples were obtained from early pregnant woman and examined with ELISA for anti-HCMV antibody IgG and IgM. After artificial abortion,chorionic villus and decidua were also examined with polymerase chain reaction (PCR) for HCMV-DNA. When the results of PCR were positive, pathological changes of these chorionic villus and decidua were analyzed.
RESULTSThe results showed that only 10 samples were PCR positive while IgG and/or IgM antibody to HCMV was positive. After infection with HCMV, different changes occurred in chorionic villus and decidual trophoblastic cells placental villus were hyperplasic and decidua cells degenerated and necrotized followed by lymphocytes infiltration.
CONCLUSIONThese pathological changes may be one of pathogenic factors of HCMV.
