Anti-SARS virus activities of different recombinant human interferons in cell culture system.
- Author:
Zhao-jun DUAN
1
;
Li-lan ZHANG
;
Zhi-ping XIE
;
Zhi-ai YU
;
Li-ping ZHANG
;
Bin ZHANG
;
Yong-qing LIU
;
Jian-wei WANG
;
Wu-ping LI
;
Cheng-hai ZHANG
;
Xue-jun MA
;
Yue-long SHU
;
Shu-min DUAN
;
De-xin LI
;
Yun-de HOU
Author Information
- Publication Type:Journal Article
- MeSH: Antiviral Agents; pharmacology; Cell Line, Tumor; Humans; Interferon Type I; pharmacology; Interferon-alpha; pharmacology; Recombinant Proteins; SARS Virus; drug effects; Severe Acute Respiratory Syndrome; drug therapy; virology
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the anti-SARS virus activities of different recombinant human interferons on the cell culture system.
METHODSAnti-SARS virus activities of interferons were determined by using CPE inhibition test in human skeletal muscle sarcoma (Rda) cell culture.
RESULTSThe average minimum amount of interferon alpha 2b, alpha 1b, beta 1b or omega 1b to inhibit 50% CPE in Rda cell culture was (160.5+/-129.5) IU/ml, (149.0+/-71.7) IU/ml, (69.5+/-61.5) IU/ml, (87.3+/-47.1) IU/ml, respectively or (0.6+/-0.5) ng/ml, (10.6+/-5.1) ng/ml, (3.5+/-3.1) ng/ml, (0.9+/-0.5) ng/ml, respectively.
CONCLUSIONAll the tested recombinant interferons showed anti-SARS virus activities on the Rda cell culture with different sensitivities.
