Detection of Epstein-Barr virus in T cell lymphoma and clinicopathologic analysis.
- Author:
Zu-gen HE
1
;
Yan-ping HUANG
;
Xiu-chan GUO
;
Dong-mei LIN
;
Yi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; DNA, Viral; genetics; Epstein-Barr Virus Infections; pathology; virology; Female; Herpesvirus 4, Human; genetics; isolation & purification; Humans; Lymphoma, T-Cell; pathology; virology; Male; Middle Aged; Tumor Cells, Cultured
- From: Chinese Journal of Experimental and Clinical Virology 2003;17(3):229-233
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.
METHODSSixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).
RESULTSEBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.
CONCLUSIONSThis study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.
