The Hemostatic Effect and Prognosis of Endoscopic Ethanol Injection in Bleeding Peptic Ulcer.
- Author:
Yong Bum YOON
1
;
In Sung SONG
;
Chung Yong KIM
;
Hyun Chae CHUNG
;
Yong Tae KIM
;
Joo Sung KIM
;
Dong Ho LEE
;
Tae Ho KIM
;
You Sun KIM
;
Jin Hyuk LEE
;
Min Jung PARK
;
Kuk Lae LEE
;
Il Joo CHOI
;
Kyeong Mi LEE
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Endoscopic injection therapy;
Endoscopic ethanol injection;
Bleeding pep-tic
- MeSH:
Emergencies;
Ethanol*;
Hemorrhage*;
Hemostasis;
Hospitalization;
Humans;
Length of Stay;
Mortality;
Peptic Ulcer*;
Prognosis*
- From:Korean Journal of Gastrointestinal Endoscopy
1999;19(3):337-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND AIMS: Endoscopic injection therapy improves the outcome in bleeding peptic ulcer, but the optimum regimen is unknown. Although endoscopic injection therapy is effective in controlling initial hemorrhage from a peptic ulcer, between 10% to 30% of patients suffer rebleeding. The aim of this study was to evaluate the initial and ultimate success rate of hemostasis, the rebleeding rate, hospital stay (days), and the emergency operation rate in patients who had undergone endoscopic ethanol injection for bleeding peptic ulcer. METHODS: Thirty nine patients presented with active bleeding (spurting), visible vessels, or blood clots on endoscopic findings were given an endoscopic ethanol injection with a total of 1.0-3.0 ml of ethanol. The initial and ultimate success rate of hemostasis, rebleeding rate, and emergency operation rate after the endoscopic injection was evaluated. RESULTS: 1) The initial success of hemostasis was 38/39 (97.4%). 2) The rebleeding rate after ethanol injection was 8/39 (20.5%). 3) The success rate of the second trial of ethanol injection was 3/8 (37.8%). 4) Emergency operations were conducted in5/39 (12.8%). 5) The ultimate success rate of hemostasis was 34/39 (87.2%). 6) There were no mortalities [0/39 (0%)] related to the ethanol injections and bleeding peptic ulcers. 7) There were no complications [0/39 (0%)] related to the ethanol injections. 8) The mean duration of hospitalization was 9.5 4.5 days. CONCLUSIONS: Endoscopic ethanol injection in the treatment of bleeding peptic ulcers was as effective and safe as any other injection or mechanical hemostatic method. Further prospective studies or endoscopic trials for hemostasis are needed to reduce the rebleeding rate and emergency operation rate of bleeding peptic ulcer.
