Effect of fructus corni polysaccharides on damaged sexual function of male rats.
- Author:
Xianglong SHAO
1
;
Qiong LUO
;
Qin QIN
;
Gaokun QIU
;
Zhuoneng LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cornus; chemistry; Female; Male; Penile Erection; drug effects; Polysaccharides; pharmacology; toxicity; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; drug effects; Sexual Dysfunction, Physiological; chemically induced; Testis; drug effects; physiology
- From: China Journal of Chinese Materia Medica 2010;35(6):772-775
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of Fructus Corni polysaccharides (FCP) on sexual function of hemicastrated rats.
METHOD70 male SD rats are randomly divided into 7 groups with their right testis extirpated except for normal control group. Normal control group and negative control group are given saline (ig) while positive control group are injected hypodermically testosterone propionate at dose of 2 mg x kg(-1) x d(-1). FCP control groups are given FCP separately at dose of 10, 50, 100, 150 mg x kg(-1) x d(-1) (ig). Mating test and erective test are observed. The levels of serum sex hormone T, LSH, FSH, E2 are detected with the Radioimmunoassay (RIA).
RESULTIncubation period of penis erection and mounting are shortened in FCP control groups and positive control group, and the percentage of mounting rats is increased. The level of serum sex hormone T is increased, but estradiol level is reduced. The organ coefficient of foreskin gland and seminal vesicle-prostate gland as well as sperm count and vigor are increased significantly (P < 0.01 or P < 0.05).
CONCLUSIONFCP can increase the sexual function of hemicastrated rats. The mechanism is probably through adjustment of the hypothalamus-pituitary-gonadal axis.
