Effects of Sanwushaoxie decoction on IL-18, TNF-alpha, IL-4 and IL-10 in patients with rheumatoid arthritis.
- Author:
Fan DING
1
;
Yanchun ZHANG
;
Yijie CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Antirheumatic Agents; therapeutic use; Arthritis, Rheumatoid; blood; diagnosis; drug therapy; Cells, Cultured; Cytokines; blood; Humans; Immunologic Factors; blood; Interleukin-10; blood; Interleukin-18; blood; Interleukin-4; blood; Interleukin-6; blood; Prescriptions; Prognosis; Reference Values; Severity of Illness Index; Tumor Necrosis Factor-alpha; blood
- From: China Journal of Chinese Materia Medica 2010;35(6):790-793
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the therapeutic effects of Sanwushaoxie decoction on alternations of serum cytokines in patients with rheumatoid arthritis (RA).
METHODSixty-three (63) RA patients were selected and randomly divided into 2 groups, with the treatment group administered with Sanwushaoxie decoction, one prescription, 2 times a day, while patients in the control group were given Common Threewingnut Root polyglycoside 20 mg a time, 3 times a day. The treatment was lasted for 60 days. Serum concentrations of IL-6, TNF-alpha, IL-4, IL-10 were observed during the treatment.
RESULTThe clinical effecacy and the experimental indexes were significantly improved in the treatment group than those did in the control group (P < 0.01, P < 0.05). There were significant differences of serum levels of 4 cytokines within the treatment group before and after the treatment (P < 0.01, P < 0.05). The serum levels of IL-4, IL-10 were significantly increased in treatment group compared with those did in the control group (P < 0.01).
CONCLUSIONSanwushaoxie decoction is an effective agent in regulating cytokines, improving symptoms and experimental indexes in patients with RA.
