Antidysmenorrheic effects of Radix angelica and Rhizoma Chuanxiong with different proportions and preparation methods on dysmenorrhea model mice.
- Author:
Huan WANG
1
;
Yuping TANG
;
Jianming GUO
;
Anwei DING
;
Weixia LI
;
Wei JIANG
;
Jinao DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apiaceae; chemistry; Behavior, Animal; drug effects; Calcium; metabolism; Chemistry, Pharmaceutical; Disease Models, Animal; Drugs, Chinese Herbal; chemistry; pharmacology; therapeutic use; Dysmenorrhea; drug therapy; metabolism; pathology; Female; Mice; Nitric Oxide; metabolism; Rhizome; chemistry; Uterus; drug effects; metabolism; pathology
- From: China Journal of Chinese Materia Medica 2010;35(7):892-895
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Radix Angelica and Rhizoma Chuanxiong with different proportions (1 : 0, 2 : 1, 1.5 : 1, 1 : 1, 1 : 1.5, 1 : 2, 0 : 1), different extraction in order (by water, by ethanol, firstly by alcohol then by water) on dysmenorrhea model mice in order to observe their compatibility rules and material foundation.
METHODThe mice model of primary dysmenorrhea was used to study the effect of Radix Angelica and Rhizoma Chuanxiong with different proportions and preparation methods on writhing response and the levels of nitric oxide and calcium ion in mice uterine tissue.
RESULTDanggui-Chuanxiong (1. 5 : 1) and solution extracted firstly by alcohol then by water showed the strongest effect on primary dysmenorrhea by reducing the writhing times, increasing nitric oxide (NO) concentration and reducing calcium ion (Ca2+) concentration in uterine tissue.
CONCLUSIONRadix Angelica and Rhizoma Chuanxiong with different proportions and preparation methods showed different antidysmenorrheic trend on dysmenorrhea model mice, which was related with the containing constituents.
