Effect of Yunnan Baiyao capsules on the socket healing of impacted mandibular third molar extraction.
- VernacularTitle:口服云南白药对下颌智齿拔牙创愈合影响的随机双盲对照研究
- Author:
Kai ZHANG
1
;
Xing WANG
;
Wei ZHANG
;
Ji-zhi ZHAO
;
Hui DONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Bone Regeneration; drug effects; Capsules; Double-Blind Method; Drugs, Chinese Herbal; administration & dosage; pharmacology; Female; Humans; Male; Mandible; surgery; Middle Aged; Molar, Third; surgery; Phytotherapy; Tooth Extraction; adverse effects; Tooth Socket; drug effects; Tooth, Impacted; surgery; Wound Healing; drug effects; Young Adult
- From: Chinese Journal of Stomatology 2012;47(4):199-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of the traditional Chinese medicine Yunan Baiyao on the socket healing of impacted mandibular third molar extraction.
METHODSA total of 200 patients requiring extractions of impacted mandibular wisdom teeth were randomized into the treatment group and the control group in a double-blinded manner, and Yunan Baiyao capsules or placebo capsules (2 g/d) were orally administered for 28 days after the operation. Dental quantitative CT scan was performed, and the volume and density of new bone at the extraction site were measured two month after operation.
RESULTSA total of 188 patients completed the study. No adverse events related to the medication occurred. The volume of new bone was (477.39 ± 166.47) mm(3) in the treatment group and (442.65 ± 143.58) mm(3) in the control group, which was not significantly different between the two groups. The density of new bone was (296.90 ± 37.94) mg/cm(3) in the treatment group and (298.54 ± 40.21) mg/cm(3) in the control group, which was not significantly different between the two groups. The number of the teeth root, the impacted conditions, whether or not retainning the alveolar septum, suturing soft tissues of the extraction site and blood clot formation within 1 week after operation were significantly correlated with the volume of new bone.
CONCLUSIONSYunnan Baiyao capsules has no effect on the volume and density of new bone at the extraction site two months after operation following extractions of impacted mandibular third molars.