Preparation of gemcitabine polybutylcyanoacrylate nanoparticles.
- Author:
Le-song HUANG
1
;
Chun-xia WANG
;
Zhi-liang CHEN
;
Jia WAN
;
Xi-qing YAN
;
Gang DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Deoxycytidine; analogs & derivatives; chemical synthesis; Drug Delivery Systems; Enbucrilate; chemical synthesis; Nanoparticles; chemistry
- From: Journal of Southern Medical University 2007;27(11):1653-1656
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP).
METHODSAccording to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design.
RESULTSThe mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%.
CONCLUSIONAn optimized nanoparticular drug delivery system is obtained by emulsion polymerization.
