Effects of 5F from Pteris semipinnate L on growth of human pathological scars in nude mice.
- Author:
Yun-song ZHANG
1
;
Jing-hua HE
;
Shao-jun LUO
;
Ye-yang LI
;
Min LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cicatrix; drug therapy; metabolism; Collagen Type I; metabolism; Drugs, Chinese Herbal; therapeutic use; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Plant Extracts; therapeutic use; Pteris; chemistry; Transforming Growth Factor beta1; metabolism
- From: Journal of Southern Medical University 2007;27(11):1677-1680
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.
METHODS5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.
RESULTSAdministration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.
CONCLUSION5F could effectively inhibit the growth of pathological scars in nude mice.
