Effect of branched-chain amino acid-rich parenteral nutrition on protein metabolism after partial hepatectomy in rats with liver cirrhosis.
- Author:
Jie CAO
1
;
Shi-min LUO
;
Li-jian LIANG
;
Wen-jie HU
Author Information
- Publication Type:Journal Article
- MeSH: Albumins; metabolism; Amino Acids, Branched-Chain; administration & dosage; therapeutic use; Animals; Hepatectomy; Insulin-Like Growth Factor I; metabolism; Liver Cirrhosis; therapy; Parenteral Nutrition; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2007;27(11):1721-1723
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of parenteral nutrition (PN) with branched-chain amino acid supplementation on protein metabolism after partial hepatectomy in rats with liver cirrhosis.
METHODSEighteen rats with liver cirrhosis were randomly divided into pre-operation group (n=6), post-operation 8.5% Novamin PN group (n=6) and post-operation 10% Hepa PN group (n=6), with 6 normal rats severing as the normal control group. Five days after the operation, serum albumin (ALB), insulin-like growth factor I (IGF-1) and plasma amino acid spectrum were measured, and ALB mRNA level in the liver was assayed using RT-PCR.
RESULTSPostoperative serum ALB was similar between 10% Hepa PN and 8.5% Novamine PN groups, but the rats in the latter group showed significantly increased serum IGF-1 level, Fischer ratio and hepatic ALB mRNA expression (P<0.05).
CONCLUSIONAdministration of PN with branched-chain amino acid supplementation can ameliorate plasma amino acid spectrum and increase protein synthesis in rats with liver cirrhosis after partial hepatectomy.
