Association of galectin-3 and E-cadherin expressions with lymph node metastasis of colon cancer.
- Author:
Zong-hui WU
1
;
Lu GAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; analysis; genetics; Cadherins; genetics; Colonic Neoplasms; genetics; pathology; Female; Galectin 3; genetics; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; Young Adult
- From: Journal of Southern Medical University 2007;27(11):1731-1733
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation between the expressions of galectin-3 and E-cadherin and lymph node metastasis of colon cancer.
METHODSImmunohistochemistry was employed to examine the expressions of E-cadherin and galectin-3 in 37 colon cancer samples, among which 21 samples underwent RT-PCR for E-cadherin and galectin-3 mRNA expressions. The correlation of E-cadherin and galectin-3 expressions with lymph node metastasis of the tumor was analyzed.
RESULTSThe positivity rate of galectin-3 expression was 83.8% (31/37) in these samples. Of the tumor cases with lymph node metastasis, 94.7% (18/19) of the tumors were positive for galectin-3 expression, a rate significantly higher than that in non-metastatic cases. The positivity rate of E-cadherin expression was 59.5% (22/37) in the total cases, and 47.4% (9/19) in the metastatic cases, significantly lower than that in the non-metastatic cases.
CONCLUSIONGalectin-3 and E-cadherin expressions are associated with lymph node metastasis of colon cancer and may serve as potential prognostic indicators for colon cancer patients.
