Pentoxifylline promotes learning and memory function of aging rats and mice with induced memory impairment.
- Author:
Rui HU
1
;
Bing-xiang YUAN
;
Lian-zhen SU
;
Xia-zhen WEI
;
Li-mei ZHAO
;
Jun KANG
;
Dong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aging; Animals; Behavior, Animal; drug effects; Ethanol; Maze Learning; drug effects; Memory; drug effects; Memory Disorders; chemically induced; Mice; Pentoxifylline; pharmacology; Rats; Rats, Sprague-Dawley; Scopolamine Hydrobromide
- From: Journal of Southern Medical University 2007;27(11):1734-1737
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of pentoxifylline on rats and mice with learning and memory dysfunctions.
METHODSMorris water maze test was used to observe the effects of pentoxifylline on learning and memory of naturally aging rats, and jumping stand test was performed to examine its effects in promoting the learning and memory functions in mice with scopolamine- and ethanol-induced memory dysfunctions.
RESULTSIn aging rats, pentoxifylline at high, moderate and low doses all significantly reduced the latency of platform finding in the place navigation test (P<0.01 or P<0.05 ), and increased the quadrant searching frequency in the spatial probe test (P<0.05). Pentoxifylline at the 3 doses significantly increased the latency of electrification (P<0.01 or P<0.05) and decreased the times of error (P<0.05) of the mice as compared with scopolamine- treated group. Pentoxifylline also improved ethanol-induced memory dysfunction in the mice, but the changes in the performance of the mice were not statistically significant.
CONCLUSIONPentoxifylline can improve the learning and memory abilities of rats and mice.
