Expression of hepatocyte growth factor and its receptor in gastric cancer.
- Author:
Jun-zhong CHEN
1
;
Yong ZHAO
;
Jia-feng XU
;
Qing LIU
;
Sheng-huo LIU
;
Hong-de ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Hepatocyte Growth Factor; metabolism; Humans; Male; Middle Aged; Proto-Oncogene Proteins c-met; metabolism; Stomach Neoplasms; metabolism; pathology; Young Adult
- From: Journal of Southern Medical University 2007;27(11):1771-1773
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the role of expression of hepatocyte growth factor (HGF) and its receptor (c-Met) in gastric cancer.
METHODSThe expression of HGF and c-Met was detected with SABC immunohistochemistry in 44 specimens of gastric cancer, 20 chronic superficial gastritis, 10 chronic atrophic gastritis and 16 gastric ulcer tissues.
RESULTSNo positive expression of HGF/c-Met was found in the chronic superficial gastritis specimens. The positivity rates of HGF in the gastric cancer was 72.7% (32/44), significantly higher than that in chronic atrophic gastritis [20% (2/10), P<0.005] and gastric ulcer [37.5% (6/16). P<0.025]. The positivity rates of c-Met in gastric cancer [77.3% (34/44)] was also significantly higher than that in chronic atrophic gastritis [40% (4/10), P<0.05] and gastric ulcer [37.5% (6/16), P<0.025].
CONCLUSIONCo-expression of HGF and c-Met in gastric cancer may promote the progression of the malignancy, and also opens a new pathway for the therapy of gastric cancer.
