Effect of short-term intensive treatment with insulin pump on beta cell function and the mechanism of oxidative stress in newly diagnosed type 2 diabetic patients.
- Author:
Qing-bin ZHAO
1
;
Hui-fang WANG
;
Chao-feng SUN
;
Ai-qun MA
;
Chang-cong CUI
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Blood Glucose; Diabetes Mellitus, Type 2; blood; drug therapy; Female; Humans; Insulin; blood; Insulin Infusion Systems; Insulin-Secreting Cells; physiology; Male; Malondialdehyde; blood; Middle Aged; Oxidative Stress; Superoxide Dismutase; blood
- From: Journal of Southern Medical University 2007;27(12):1878-1879
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of short-term intensive treatment with insulin pump on beta cell function and the mechanism of oxidative stress in newly diagnosed type 2 diabetic patients.
METHODSTotally 120 newly diagnosed type 2 diabetic patients were treated with insulin pump for 2 weeks. The levels of fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG), homeostatic model assessment of the insulin secretion index and insulin resistance index (HOMA-beta and HOMAIR, respectively), blood malondialdehyde (MDA) and superoxide dismutase (SOD) were measured before and after insulin pump treatment.
RESULTSAfter insulin pump treatment, FPG, 2hPG, HOMAIR and blood MDA were significantly decreased (P<0.01), while HOMA-beta and blood SOD were significantly increased (P<0.01).
CONCLUSIONShort-term intensive treatment with insulin pump can effectively improve beta cell function probably by decreasing oxidative stress in newly diagnosed type 2 diabetic patients.
