Preliminary study of diffusion tensor imaging in treatment response assessment of major depression.
- Author:
Jun XIA
1
;
Yi LEI
;
Hua-jian XU
;
Wei FENG
;
Xiao-liu WU
;
Xiao-lin LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Bipolar Disorder; drug therapy; Brain; pathology; Case-Control Studies; Depressive Disorder, Major; drug therapy; Diffusion Magnetic Resonance Imaging; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin Uptake Inhibitors; therapeutic use; Treatment Outcome
- From: Journal of Southern Medical University 2007;27(12):1905-1907
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the value of diffusion tensor imaging (DTI) in therapeutic effect evaluation of major depression.
METHODSEighteen patients who met the CCMD-3-R criteria for major depression or bipolar disorder (with depressed episode and total score no less than 18 for 17 items of Hamilton Depression Rating Scale) and 13 aged-matched controls were examined by routine magnetic resonance imaging (MRI) and DTI. DTI were used to determine fractional anisotropy (FA) in the preselected white matter regions. All the patients with major depression received treatment with selective serotonine reuptake inhibitor (SSRI) for 6-8 weeks, and the efficacy were assessed by Hamilton Depression Scale, Hamilton Anxiety Scale (HAMA), and Clinical Global Impression (CGI) scale.
RESULTSThe total response rate to fluoxetine was 67%, and significant improvement was observed in 56% of the patients while 33% failed to respond after 8 weeks of treatment. The depressed subjects failing to respond to the treatment had a significant lower FA of the frontal white matter than those responding favorably to the treatment and the healthy control subjects.
CONCLUSIONDTI may identify the microstructural abnormality in the white matter, which is associated with a low remission rate of major depression.
