Cytology of Follicular Dendritic Cell Sarcoma on Intraoperative Touch Imprint Smears: A Case Report.
10.4132/KoreanJPathol.2009.43.6.589
- Author:
Ju Young SONG
1
;
Xian Ji JIN
;
Jee Young HAN
;
Lucia KIM
;
In Suh PARK
;
Joon Mee KIM
;
Young Chae CHU
;
Suk Jin CHOI
Author Information
1. Department of Pathology, Inha University Hospital, Incheon, Korea. 204058@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Dendritic cell;
Follicular;
Sarcoma;
Cytology;
Lymph nodes
- MeSH:
Cytoplasm;
Dendritic Cell Sarcoma, Follicular;
Dendritic Cells;
Dendritic Cells, Follicular;
Hepatitis;
Humans;
Liver Cirrhosis;
Lymph Nodes;
Lymphocytes;
Lymphoma;
Male;
Middle Aged;
Sarcoma
- From:Korean Journal of Pathology
2009;43(6):589-593
- CountryRepublic of Korea
- Language:English
-
Abstract:
Follicular dendritic cell (FDC) sarcoma is a neoplastic proliferation of FDCs. Because its cytologic findings can vary widely, both the cytomorphology and histopathology of FDC sarcoma can impose a significant diagnostic dilemma. We present cytologic features of FDC sarcoma assessed by intraoperative touch imprint. Intra-abdominal lymphadenopathies were noted in 54-year-old male with hepatitis B-virus associated liver cirrhosis. In contrast to cytologic features of classical FDC sarcoma, the tumor cells featured a large epithelioid or Reed-Sternberg cell-like shape scattered in a background with abundant inflammatory cells, which led to a mistaken diagnosis of malignant lymphoma. However, in accordance with cytologic features previously described in the literature, the tumor cells were characterized by a fragile cytoplasm with cytoplasmic processes in dendritic or reticulated patterns reminiscent of the ultrastructural features of FDC. Cytoplasmic features rendering nuclei with a tendency to form clusters or syncytial aggregates associated with reactive lymphocytes appear to be the most valuable finding in diagnosis of FDC sarcoma.
