Researches on genetics and genetic epidemiology of common complex diseases: challenge and strategies.
- Author:
Dong-feng GU
1
Author Information
1. Department of Evidence Based Medicine and Population Genetics, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMC, Beijing 100037, China. gudongfeng@vip.sina.com
- Publication Type:Journal Article
- MeSH:
Genetic Markers;
Genetic Predisposition to Disease;
Genetics, Population;
Humans;
Linkage Disequilibrium;
Molecular Epidemiology;
Phenotype
- From:
Acta Academiae Medicinae Sinicae
2006;28(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of human genome project, increased genetic and population-based association studies are focused on the identification of the underlying susceptibility genes and contributions from gene-environment interaction to common complex diseases. Whole-genome association study with high-density single nucleotide polymorphisms is one of the most important milestones in that process. However, problems still exist in study design, data processing, and results interpretation. Large-scale cohort study or population-based case-control design with sufficient statistical power, new approaches to assess the gene-gene and gene-environment interactions, as guarantee of the consistency and replicability of these researches are crucial in the exploration of the causes of these common complex diseases.
