Linkage analysis of the polymorphism at D17S1878 site with essential hypertension.
- Author:
Ling-yu FU
1
;
Yan-yan ZHAO
;
Jing-pu SHI
;
Hui LI
;
Wen-li WANG
;
Jing-yu LU
;
Hong LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Genetic Linkage; Genetic Predisposition to Disease; genetics; Genotype; Humans; Hypertension; genetics; Male; Microsatellite Repeats; genetics; Middle Aged; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; genetics
- From: Acta Academiae Medicinae Sinicae 2006;28(2):129-133
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the linkage of the polymorphism at D17S1878 site with susceptible gene of essential hypertension.
METHODSForty-five pedigrees from the high prevalence region of the hypertension were collected. The polymorphism of D17S1878 site was genotyped with genetic analyzer and gene-scan software. Discordant sib pair analysis and affected sib pair analysis were used in linkage analysis.
RESULTSThere were significant differences in the age, male, alcohol-consuming, over-salt intake, average systolic pressure, average diastolic pressure, waist-to-hip-ratio, total cholesterol, high-density lipoprotein, and low density lipoprotein between the hypertensive sib and the normotensive sib (P < 0.05). There were eleven alleles at D17S1878 site, and the allele frequency was significantly different between the hypertensive and normotensive sibs (P < 0.05). Forty-three pedigrees were analyzed with affected sib pair analysis (t = 3.05, P < 0.05).
CONCLUSIONThe polymorphism of D17S1878 may be linked with susceptible genes of essential hypertension.
