Correlation between periodontal disease and coronary atherosclerotic heart disease.
- Author:
Ping LIU
1
;
Yun ZHANG
;
Su-jia WANG
;
Feng-he ZHANG
;
Pei-hui ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; C-Reactive Protein; analysis; Case-Control Studies; Coronary Artery Disease; blood; complications; Dental Plaque Index; Female; Humans; Interleukin-1; blood; Male; Middle Aged; Periodontal Diseases; blood; complications; pathology; Periodontal Index; Risk Factors; Tumor Necrosis Factor-alpha; analysis
- From: Acta Academiae Medicinae Sinicae 2006;28(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between coronary atherosclerotic heart disease (CAD) and periodontal disease (PD).
METHODForty-five patients with CAD (CAD group) and 40 patients without CAD (control group) were compared with their pathological changes of periodontal tissues and inflammatory markers [high sensitive C reactive protein (hsCRP), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha)].
RESULTSUnivariate analysis showed that the prevalence of PD was 84.44% in CAD group and 22.50% in control group (P < 0.01). The levels of hsCRP, IL-1beta, and TNF-alpha were (5.75 +/- 1.26) mg/L, (10.32 +/- 2.96) ng/L, and (9.17 +/- 2.14) ng/L in CAD group and (1.13 +/- 0.73) mg/ L, (2.87 +/- 1.45) ng/L, and (5.84 +/- 1.96) ng/L in control group (P < 0.01). Gingival index and plaque index were statistically different between two both groups (P < 0.01). Logistic regression analysis showed that in addition to pulse pressure and low density lipoprotein cholesterol, periodontal disease index was a higher risk factor of CAD. Its relative risk was 1.217 (95% CI was 1.120-1.805, P < 0.05).
CONCLUSIONPD can cause CAD. The improvement of public oral health plays an important role in the prevention and treatment of CAD.
