Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese.
- Author:
Guang YANG
1
;
Ya-jun DENG
;
Chun-xia YAN
;
Dong-ying WU
;
Song-nian HU
;
Bo-feng ZHU
;
Sheng-bin LI
;
Xiu-qing ZHANG
;
Yao LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-B27 Antigen; classification; genetics; Humans; Male; Polymerase Chain Reaction; Sequence Analysis, DNA; Spondylitis, Ankylosing; genetics
- From: Acta Academiae Medicinae Sinicae 2006;28(2):240-243
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the frequencies distribution of human leukocyte antigen (HLA)-B27 subtypes in unrelated healthy Chinese.
METHODPolymerase chain reaction sequence-based typing (PCRSBT) was used to determine HLA high-resolution genotypes of 825 unrelated healthy Chinese.
RESULTSA total of 25 HLA-B27-positive individuals and 8 HLA-B27 subtypes were detected. These subtypes and their corresponding frequencies were B * 2704 (30.77%) , B * 2705 (23.08%), B * 2707 (19.23%), B * 2711 (7.69%), B * 2712 (7.69%), B * 2701 (3.85%), B * 2713 (3.85%) and B * 2721 (3.85%).
CONCLUSIONThe data obtained through PCR-SBT method may serve as important reference for the research of relationship between HLA-B27 subtypes and some diseases such as ankylosing spondylitis.
