Advances in molecular biology of extended-spectrum beta-lactamase.
- Author:
Qian XIANG
1
;
Xue-fu YOU
;
Jian-dong JIANG
Author Information
1. Department of Pharmacology and Toxicology, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Molecular Biology;
beta-Lactamases;
classification;
genetics
- From:
Acta Academiae Medicinae Sinicae
2006;28(2):298-303
- CountryChina
- Language:Chinese
-
Abstract:
Extended-spectrum beta-lactamases (ESBLs), mediated by plasmids, can hydrolyze and cause resistance to penicillins, broad spectrum-cephalosporins, and monobactams. Most ESBLs are derived from the widespread broad-spectrum beta-lactamases TEM-1 and SHV-1. There are also other families of ESBLs, including CTX-M and OXA-type enzymes as well as novel unrelated beta-lactamases. This article reviews recent advances in the classification, characteristics, and other molecular biological aspects of ESBLs.
