Collection of a Chinese pedigree with Parkinson's disease and linkage analysis of nine susceptibility genes.
- Author:
Hao SUN
1
;
Chang-Jun ZHANG
;
Qing SHU
;
You-Yong TIAN
;
Lei SHI
;
Jian-Kun YU
;
Ya-Ping QIAN
;
Jia-You CHU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; China; Female; Genetic Linkage; Genetic Predisposition to Disease; Genotype; Humans; Microsatellite Repeats; Middle Aged; Parkinson Disease; genetics; Pedigree
- From: Acta Academiae Medicinae Sinicae 2006;28(3):368-371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the susceptibility genes of a Parkinson's Disease (PD) family.
METHODSThe blood samples of a four-generation classic idiopathic PD family were collected. Two-point LOD score method was applied to analyze the linkage disequilibrium between the disease locus and microsatellite markers.
RESULTSWe studied 13 markers near the 9 genes that had been reported to be associated with PD. No obvious evidence showed that the selected markers had anything correlation with PD locus.
CONCLUSIONThese 9 genes are not the susceptibility genes of PD in this family.
