Distribution and expression of peroxisome proliferator activated receptor gamma in human pituitary adenomas.
- Author:
Yan MA
1
;
Xue-Wei XIA
;
Chang-Bao SU
;
Yan-Guo KONG
Author Information
- Publication Type:Journal Article
- MeSH: ACTH-Secreting Pituitary Adenoma; metabolism; Adult; Female; Humans; Male; Middle Aged; PPAR gamma; biosynthesis; metabolism; Pituitary Gland; metabolism; Pituitary Neoplasms; metabolism
- From: Acta Academiae Medicinae Sinicae 2006;28(3):375-377
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the distribution and expression of peroxisome proliferator activated receptor gamma (PPAR-gamma) in human pituitary adenomas.
METHODSThirty eight consecutive surgically resected pituitary adenomas and 5 normal pituitary tissues were enrolled in the study. Immunohistochemistry was used to confirm the distribution of PPAR-gamma. Expression of PPAR-gamma was evaluated by Western blot.
RESULTSPPAR-gamma immunoreactivity was located in the nucleoli of pituitary adenoma cells. PPAR-gamma was expressed in all human pituitary adenomas and normal pituitary tissues. Its expression in pituitary adenomas was significantly higher than in normal pituitary tissues (P < 0.01), and its expression in ACTH-secreting adenomas was significantly higher than in any other type of pituitary adenomas (P < 0.05).
CONCLUSIONSPPAR-gamma may play an important role in the generation, growth, and invasion of human pituitary adenomas. It may become a novel therapeutic target for these tumors.
