Pathological study of pulmonary carcinomas with spindle and/or giant cells.
- Author:
Zhen HUO
1
;
Hong-Rui LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; pathology; Adult; Aged; Aged, 80 and over; Female; Giant Cells; pathology; Humans; Lung; pathology; Lung Neoplasms; pathology; Male; Middle Aged
- From: Acta Academiae Medicinae Sinicae 2006;28(3):391-394
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pathologic features of pulmonary carcinomas with spindle and/or giant cells.
METHODSTwenty cases of pulmonary carcinomas with spindle and/or giant cells were studied by using lightmicroscopy and immunohistochemical staining.
RESULTSOf 20 cases, 15 cases were pleomorphic carcinoma (10 cases with adenocarcinoma, 3 cases with large cell carcinoma, 1 case with squamous cell carcinoma and 1 case with giant cell carcinoma) , 4 cases were spindle cell carcinoma, and 1 case was giant cell carcinoma. Immunohistochemical results showed AE1/AE3 was positive in the spindle and/or giant cell component of 19 cases, Vimentin was positive in the spindle and/or giant cell component of 20 cases, P53 was positive in 10 cases and thyoid transcription factor-1 (TTF-1) was negtive in all cases.
CONCLUSIONSPulmonary carcinomas with spindle and/or giant cells is definded as a group of poorly differentiated non-small cell carcinoma that contains a component of spindle and/or giant cells. The diagnosis is based on histopathology and immunohistochemical staining of AE1/AE3 and Vimentin.
