Effects of long-term and low-dose hormone replacement therapy on bone mineral density in postmenopausal women.
- Author:
Min NIE
1
;
Mei-Li SUN
;
Qin-Sheng GE
Author Information
- Publication Type:Journal Article
- MeSH: Absorptiometry, Photon; Bone Density; Estrogens; administration & dosage; Female; Hormone Replacement Therapy; Humans; Middle Aged; Osteoporosis, Postmenopausal; prevention & control; Progesterone; administration & dosage
- From: Acta Academiae Medicinae Sinicae 2006;28(3):421-424
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of long-term and low-dose hormone replacement therapy on bone mineral density (BMD), and the incidence of bone pain in postmenopausal women.
METHODSTotally 141 postmenopausal women were selected from the medical staff of the Peking Union Medical College Hospital. Of them, 63 women treated with low-dose sex hormone for over 5 (5-32) years were divided into hormone replacement therapy (HRT) group, and 78 never receiving HRT were divided into control group. The BMD was measured by dual energy X-ray absorptiometry (DEXA) at lumbar spine, Ward's triangle, femoral neck, trochanter, and total hip, and the incidence of bone pain was inquired.
RESULTSThe BMD in the HRT group was 9.1% higher than that in the control group (P < 0.05). The incidence of bone pain was significantly lower in the HRT group (71.4%) than that in the control group (89.7%).
CONCLUSIONLong-term and low-dose hormone replacement therapy can reduce bone loss and the incidence of bone pain.
