OBJECTIVETo explore the feasibility of the animal experimental cabin to copy the animal models with ATM/LP and low oxygen and high carbon dioxide environment.

METHODS60 SPF-class male SD rats were divided into two groups, 20 for normobaric hypoxia control experiments and the other 40 for hypobaric hypoxia control experiments. For each group, examine the pulmonary arterial pressure and carotid arterial pressure indicators of rats by using the multi-detector measurement of physiological, and observe the pulmonary vascular changes in the structure.

RESULTSThe ATM/LP and low oxygen and high carbon dioxide environment can promote the formation of pulmonary hypertension and accelerate changes in pulmonary vascular remodeling, promoting right ventricular hypertrophy.

CONCLUSIONClinical applications showed that the animal experimental cabin was observing and controlling accurately, safe, reliable, and the results was reproducible. It can successfully copy the regular low-pressure hypoxia and hypercapnia environment pulmonary hypertension model, in order to study the physiological mechanism of a variety of circulation and respiratory diseases caused by oxygen-poor and provide an experimental technology platform.