Comparison of in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes.

Author: Yanjun CHEN ¹ ; Huibin WU ; Junlin YUAN ; Lei SHI ; Rixian JIN ; Huafeng LIU ; Weizheng XIONG ; Luqi HUANG
Author Information

1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China.
Publication Type:Journal Article
MeSH: Drug Delivery Systems; methods; Liposomes; chemistry; ultrastructure; Nanospheres; chemistry; ultrastructure; Particle Size; Proanthocyanidins; chemistry
From: China Journal of Chinese Materia Medica 2010;35(2):169-172
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo prepare flexible proanthocyanidins nanoliposomes, and explore the in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes.
METHODFlexible proanthoeyanidins nanoliposomes were prepared proanthocyanidins using a film dispersion method, characterized by transmission electron microscope, and the in vitro release action was studied in different dissolution mediums using dynamic dialyse method with the content of total phenol as index.
RESULTThe in vitro release of both proanthocyanidins flexible nanoliposomes and general nanoliposomes were in accordance with Weibull distribution.
CONCLUSIONProanthocyanidins flexible nanoliposomes without pressure had similar in vitro release behavior with general nanoliposomes.