Preparation of water-soluble chitosan solid dispersion of daidzein.
- Author:
Yuebin GE
1
;
Xubin WANG
;
Weilin GUO
;
Xiaomin XIE
Author Information
- Publication Type:Journal Article
- MeSH: Calorimetry, Differential Scanning; Chitosan; chemistry; Isoflavones; chemistry; Solubility; Spectrophotometry, Infrared; Water; chemistry; X-Ray Diffraction
- From: China Journal of Chinese Materia Medica 2010;35(3):293-296
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo enhance the dissolution rate of daidzein with solid dispersion technique.
METHODSolid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.
RESULTDissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1:5 and 1:9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.
CONCLUSIONWater-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.
