Study of components in xingnaojing affecting intestine absorption of gardenia extract.
- Author:
Shouying DU
1
;
Qianyi ZHANG
;
Yang LU
;
Yongsong ZHAI
;
Qing WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; pharmacology; Gardenia; chemistry; Intestinal Absorption; drug effects; Iridoids; pharmacokinetics; Linear Models; Male; Plant Extracts; pharmacokinetics; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2010;35(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of ingredients in Xingnaojing,such as moschus, borneol and radix curcumae on intestine absorption kinetics of gardenia extract.
METHODAn in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract.
RESULTWhile gardenia extract was administered solely, the absorptive rate constant (K) of geniposide was (0.055 +/- 0.006) h(-1); But while the extract was co-administered with radix curcumae,moschus and borneol, the K were (0.060 +/- 0.001), (0.066 +/- 0.008), (0.072 +/- 0.010) h(-1), respectively. The K was (0.076 +/- 0.011) h(-1) while the extract in total formulation for Xingnaojing.
CONCLUSIONThe K, while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.
